Bad weather hampered search operations by two helicopters with extremely low visibility.
On Sunday, a small plane carrying 22 people went missing in the mountains of Nepal.
Tara Air’s planes depart from Pokhara, 200 kilometers (124 miles) east of Kathmandu, on a regular 15-minute flight to the mountain town of Chomsom. It lost contact with the airport tower shortly after takeoff.
Police officer Ramesh Thapa said there was no information on the Twin Otter plane and a search was ongoing.
“A domestic flight from Pokhara to Chomsom has lost contact,” Tara Air spokesman Sudarshan Bataura told AFP.
There were 19 passengers and three crew members on board, he said.
Interior Ministry spokesman Phanindra Mani Pokharel said two helicopters had been deployed for search operations, but added that visibility was low.
“Severe weather could hinder search operations. Visibility is too poor to see anything,” Beaucarel said.
Jomsom is a popular trekking destination in the Himalayas, about a 20-minute flight from Pokhara.